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Causes of skin cancer

Ultraviolet light from the sun is the main cause of skin cancer. Skin cancer is becoming more common and there are several possible reasons for this. People are living longer (and so their lifetime sun exposure is greater). They often have more time and money for outdoor recreation and holidays in sunny climates and many people still consider suntans to be healthy and attractive. It is likely that most skin damage from ultraviolet radiation occurs before the age of 20. It is thought that a build-up of overexposure to the sun over a period of several years can lead to the development of basal cell and squamous cell skin cancers.

Black- or brown-skinned people have a very low risk of developing skin cancer because the melanin pigment in their skin gives them protection. A fair-skinned person who tends to go red or freckle in the sun will be most at risk. Children and young adults who have been overexposed to the sun have an increased risk of developing some form of skin cancer. This will not show up until later on in life – usually after about age 40, and often not until the 60s or 70s.

The regular use of sunlamps and sunbeds increases the risk of developing skin cancer.

Areas of skin that have been badly burned, or have long-term inflammation have an increased risk of squamous cell carcinoma.

Radiotherapy given to treat other conditions can sometimes cause skin cancers in the treatment area later in life.

People who have to take drugs which lower their immunity (immunosupressants) – for example, after a kidney transplant – are also at increased risk of getting skin cancer.

Other rare possible causes are overexposure to certain chemicals at work, including coal tar, soot, pitch, asphalt, creosotes, paraffin waxes, petroleum derivatives, hair dyes, cutting oils and arsenic. You should wear protective clothing if you are handling these substances frequently.

Some people with rare hereditary conditions have a higher risk of developing skin cancer. However, non-melanoma skin cancers are not caused by inherited faulty genes that can be passed on to other family members and so other members of your family are not at a higher risk of developing skin cancer.

What are the symptoms?

Both basal cell and squamous cell carcinomas can appear in a variety of forms.

Basal cell cancers can develop as a small lump on your skin which is smooth and pearly or waxy in appearance. It may bleed sometimes or develop a crust. It may begin to show signs of healing and yet never quite does. Instead, you may see a flat, red spot, which is scaly and crusty. Sometimes there is just a firm, red lump. Skin cancers are usually painless and grow slowly. They can appear anywhere on your body but are most likely to occur on exposed skin, especially your face.

Squamous cell carcinomas often have a scaly appearance. Sometimes they have a hard, horny cap and can feel tender to touch. They are also found on the face, bald scalps, arms, backs of hands and lower legs.

If you notice anything unusual on your skin which does not go away within a month, you should show it to your doctor. There are, however, many other conditions that may appear in the skin which are not cancer, particularly among older people. You may still wish to have these treated for cosmetic reasons.

Signs and symptoms of non-melanoma skin cancer:

Most likely to appear on face, neck or other exposed skin. 

Small lump- smooth or waxy- may bleed- may develop a crust - may be itchy

Flat, red spot -- scaly and crusty

Firm, red lump -- painless, growing slowly

Lump with scaly or horny top

How it is diagnosed

Usually you begin by seeing your GP (family doctor), who will examine you and decide whether to refer you to a hospital specialist for further tests and treatment. A specialist in skin diseases is called a dermatologist. Your treatment may be carried out by the dermatologist. Depending on the area of the body affected by the cancer and the type of treatment that is necessary you may be referred to a general surgeon, a plastic surgeon or a clinical oncologist (radiotherapy and chemotherapy specialist).

The specialist will be able to tell a great deal from a simple examination of the affected area of skin. However, it is not always possible to distinguish between skin cancers and benign conditions by examination alone. You may be advised to have a biopsy. This is a quick and simple procedure which can usually be done in the outpatients department using a local anaesthetic. The doctor will remove all or part of the lump and send it to the laboratory for analysis under a microscope by a pathologist.

As basal cell carcinomas almost never spread, there will probably be no need for further tests as long as the cancer has been completely removed.

As squamous cell carcinomas may occasionally spread, your doctor may want to do one or two other tests as well as the physical examination and biopsy. This is to make sure that there is no need for further treatment. The tests are particularly important if you have had treatment for skin cancer before and it has come back (recurred). During the physical examination, the doctor will probably feel the lymph glands close to the cancer to see if any of them are enlarged. You will probably be asked to have a chest x-ray and possibly blood tests to assess your general health. If any other tests are necessary your doctor will discuss these with you

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تحقیق در مورد سرطان پوست

لینک دانلود و خرید پایین توضیحات

دسته بندی : وورد

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سرطان پوست

پوست بزرگترین عضو بدن و وظیفه آن ذخیره چربی ـ خنک نگهداشتن بدن و ساختن ویتامین D در بدن است و بدن را از عفونت، نور، از دست رفتن آب و سایر مایعات و جراحت حفاظت می کند.

سرطان پوست بیماری است که در آن سلولهای بدخیم از بافت پوست نشات می گیرند و به طور نامنظم و فزاینده ‌ای تکثیر و به طریقی از سیستم ایمنی و دفاعی بدن عبور می کنند بدون اینکه موجب عکس‌العمل تدافعی و تهاجمی در سیستم ایمنی بدن شوند. مهمترین عامل پیشتاز و مستعد سرطان پوست، جهش در DNA سلول بر اثر اشعه ماورای بنفش است که منجر به شروع آسیب سلول و سرطانی شدن آن می شود.

با توجه به نوع سلول پوستی که دچار آسیب و سرطان شده است اشکال مختلفی از سرطان پوست وجود دارد که هر کدام نشانه ها و عوارض خاص خود را دارند.

 شایع ترین اشکال سرطان پوست عبارتند از:

1- سرطان سلولهای بنیانی یا پایه (Basal Cell Carcinoma)

2- سرطان سلولهای فلسی (Squamous Cell Carcinoma )

3- سرطان سلولهای ملانوسیست ( ملانوما) ( Melanoma)

* سرطان سلول های بنیانی

سرطان سلولهای بنیانی شایع ترین نوع سرطان پوست به شمار می آید و نسبت به دیگر اشکال سلولهای سرطانی پوست خطر کمتری دارد. سرطان سلولهای بنیانی که در پایه اپیدرم (لایه خارجی پوست) قرار دارند سرعت رشد کم و آرام داشته و به ندرت گسترش می یابند.

سبب شناسی سرطان سلولهای بنیانی پوست عبارت است از: در معرض تابش نور شدید آفتاب قرار گرفتن بدن از جمله صورت، گوشها، گردن، سر، شانه ها و پشت، تماس با مواد شیمیایی مانند آرسنیک و مواد رادیو اکتیو، جراحتهای باز، سوختگی، خالکوبی و واکنشهای حساسیتی نسبت به واکسن.

افرادی که پوست و موی روشن و چشم آبی، سبز و خاکستری دارند و همچنین اشخاصی که مشاغل آنها در فضای باز است و به طور متوالی در معرض نور آفتاب هستند نیز از خطر بالا تری برای ابتلا به سرطان سلولهای بنیانی پوست برخوردارند.

* علائم هشدار دهنده سرطان بنیانی پوست

•      زخمهای بازی که خونریزی در آن پس از سه هفته یا بیشتر ترمیم نیافته باشد.

•      لکه سرخ یا حساسیتی که ممکن است حالت خشکی درد و یا خارش داشته و بهبود نیابد.

•      بر آمدگی شفافی که به رنگ صورتی- قرمز- سفید است و یا در افراد با پوستهای تیره به رنگ قهوه ای و سیاه نمایان شود و گاهی با خال اشتباه گرفته می شود.

•      لکه صورتی که با حاشیه بر آمده و فرو رفتگی خشک در مرکز آن همراه است در این مورد با رشد لکه ، رشته های نازک رگهای خونی ممکن است بر سطح آن ایجاد شود.

* سرطان سلولهای فلسی پوست

سرطان سلولهای فلسی دومین شکل شایع سرطان پوست به شمار می رود که می تواند تمام بدن از جمله لایه های مخاطی را در بر گیرد.

اکثر اشکال سرطان سلولهای فلسی مدتها به لایه اپیدرم محدود می ماند و در صورت درمان نشدن به لایه های زیرین پوست سرایت کرده و بافتهای دیگر را مورد تهاجم قرار می دهد.